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Midtown is a neighborhood in St. Louis City, and it is at the geographic center of the city. It contains the campus of Saint Louis University, Powell Hall

The boundaries of Midtown are Chouteau Avenue on the south, Jefferson Avenue on the east, Vandeventer Avenue on the west, and Delmar Boulevard and Olive Street via North Compton Avenue on the north. Midtown does not include the Grand Center Arts & Entertainment District, which is part of the Covenant Blu/Grand Center neighborhood.

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